Yokozawa T, Dong E, Oura H
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Exp Toxicol Pathol. 1997 Feb;49(1-2):117-22. doi: 10.1016/S0940-2993(97)80079-6.
The effects of a green tea tannin mixture and its individual tannin components on methylguanidine were examined in rats with renal failure. The green tea tannin mixture caused a dose-dependent decrease in methylguanidine, a substance which accumulates in the blood with the progression of renal failure. Among individual tannin components, the effect was most conspicuous with (-)-epigallocatechin 3-O-gallate and (-)-epicatechin 3-O-gallate, while other components not linked to gallic acid showed only weak effects. Thus, the effect on methylguanidine was found to vary among different types of tannin.
在肾衰竭大鼠中研究了绿茶单宁混合物及其单个单宁成分对甲基胍的影响。绿茶单宁混合物使甲基胍呈剂量依赖性减少，甲基胍是一种随着肾衰竭进展而在血液中蓄积的物质。在单个单宁成分中，（-）-表没食子儿茶素3-O-没食子酸酯和（-）-表儿茶素3-O-没食子酸酯的作用最为显著，而其他与没食子酸无关的成分作用较弱。因此，发现不同类型的单宁对甲基胍的作用有所不同。
