Nisar M, Williams C S, Ashby D, Davies P D
Sheffield Centre for Rheumatic Disease, Nether Edge Hospital.
Thorax. 1993 Dec;48(12):1257-60. doi: 10.1136/thx.48.12.1257.
Evidence from the United States has shown that tuberculin sensitivity increases with length of stay among residents in homes for the elderly, implying an increasing risk of infection. There is no evidence as to whether or not residents in homes in the United Kingdom have a similar risk.
A study was undertaken to determine whether residence in a home for the elderly increases the risk of tuberculosis infection. Over a six month period all residents in homes for the elderly in Liverpool received a tuberculin test. A health questionnaire was completed by the field team for each resident. A total of 2665 residents in homes for the elderly were surveyed.
Heaf test grade positivity declined with age, the odds ratio being 0.71 for each 10 year period. Adjusting for age, there was no change in Heaf test grade with length of stay in the home. Heaf test positivity was stronger in smokers (odds ratio 1.59) than ex-smokers (odds ratio 1.20) and non-smokers. Heaf test grade positivity was directly related to pack years. Allowing for age and smoking, the odds ratio for men compared with women for a positive test was 1.62 (95% confidence interval 1.32 to 1.99).
Heaf test positivity declines with age. Residence in a home for the elderly is not associated with increased rate of tuberculosis sensitivity. Smoking and male gender is associated with increased Heaf test positivity.
来自美国的证据表明,老年之家居民的结核菌素敏感性随居住时间延长而增加,这意味着感染风险上升。但尚无证据表明英国老年之家的居民是否存在类似风险。
开展了一项研究,以确定居住在老年之家是否会增加结核感染风险。在六个月的时间里,利物浦所有老年之家的居民都接受了结核菌素检测。现场团队为每位居民填写了一份健康问卷。共对2665名老年之家居民进行了调查。
希夫试验分级阳性率随年龄下降,每10年的比值比为0.71。在调整年龄因素后,希夫试验分级不会随着在老年之家的居住时间而变化。吸烟者的希夫试验阳性率(比值比为1.59)高于已戒烟者(比值比为1.20)和非吸烟者。希夫试验分级阳性率与吸烟包年数直接相关。在考虑年龄和吸烟因素后,男性检测呈阳性的比值比为1.62(95%置信区间为1.32至1.99),高于女性。
希夫试验阳性率随年龄下降。居住在老年之家与结核敏感性增加率无关。吸烟和男性与希夫试验阳性率增加有关。