Jeanmougin M, Manciet J R, De Prost Y, Reygagne P, Pinquier L, Dubertret L
Unité de Photodermatologie, Hôpital Saint-Louis, Paris.
Ann Dermatol Venereol. 1993;120(8):549-54.
Photosensitization to lipid-lowering fibric acid derivatives are rare. We report a case of photoallergy induced by fenofibrate, proved by a positive UVA photo-patch-test. Evolution towards persistent photosensitization is probable, since photobiological abnormalities persisted during four months after fenofibrate was discontinued. The fact that patch-tests to various benzophenones were negative is not in favour of the benzophenone group being responsible for the photosensitization reaction.
对降血脂的纤维酸衍生物的光敏反应很罕见。我们报告了1例由非诺贝特引起的光过敏病例,UVA光斑试验阳性证实了这一点。由于在停用非诺贝特后的4个月内光生物学异常持续存在,因此有可能发展为持续性光敏反应。对各种二苯甲酮进行斑贴试验结果为阴性,这一事实不支持二苯甲酮类是光敏反应的原因。