McNally P G, Raymond N T, Swift P G, Hearnshaw J R, Burden A C
Diabetes Research, Leicester General Hospital, UK.
Diabet Med. 1993 Dec;10(10):906-8. doi: 10.1111/j.1464-5491.1993.tb00005.x.
This study investigated the relationship between the development of diabetic retinopathy and pubertal status at onset of diabetes in 521 Type 1 diabetic patients diagnosed between 1950 and 1985. Pubertal status was based on age at onset (girls > or = 11 years and boys > or = 12 years). Retinopathy (all forms) developed in 112 patients (21.5%; 65 background and 47 proliferative retinopathy). For subjects diagnosed in either the prepubertal or postpubertal period, a similar proportion survived without developing retinopathy for any given duration of diabetes (chi 2 = 0.3822, p = 0.54). However, if only the postpubertal duration of diabetes is considered, then the proportion of patients surviving without retinopathy was significantly less for those diagnosed in the prepubertal period (chi 2 = 14.2, p = 0.002). This study suggests that the prepubertal duration of diabetes is an important phase and that the years prior to puberty do contribute to the risk of developing microvascular injury.
本研究调查了1950年至1985年间确诊的521例1型糖尿病患者糖尿病视网膜病变的发展与糖尿病发病时青春期状态之间的关系。青春期状态基于发病年龄（女孩≥11岁，男孩≥12岁）。112例患者（21.5%；65例为背景性视网膜病变，47例为增殖性视网膜病变）出现了视网膜病变（所有类型）。对于在青春期前或青春期后确诊的受试者，在任何给定的糖尿病病程中，未发生视网膜病变而存活的比例相似（χ2 = 0.3822，p = 0.54）。然而，如果仅考虑青春期后的糖尿病病程，那么青春期前确诊的患者未发生视网膜病变而存活的比例显著较低（χ2 = 14.2，p = 0.002）。本研究表明，糖尿病的青春期前病程是一个重要阶段，青春期前的年份确实会增加发生微血管损伤的风险。
