1型糖尿病患者中QT间期延长的患病率及其与自主神经病变的关联。意大利糖尿病研究学会神经病变研究组。

Prevalence of QT prolongation in a type 1 diabetic population and its association with autonomic neuropathy. The Neuropathy Study Group of the Italian Society for the Study of Diabetes.

作者信息

Sivieri R, Veglio M, Chinaglia A, Scaglione P, Cavallo-Perin P

机构信息

Italian Society for the Study of Diabetes, Neuropathy Study Group, Torino.

出版信息

Diabet Med. 1993 Dec;10(10):920-4. doi: 10.1111/j.1464-5491.1993.tb00007.x.

DOI:10.1111/j.1464-5491.1993.tb00007.x

PMID:8306587

Abstract

The prevalence of QT prolongation in a large random sample of Type 1 diabetic patients in Piemonte, Italy and its association with autonomic neuropathy were assessed. Three hundred and seventy-nine Type 1 diabetic patients (age 15-59) with (94, DAN+) and without (280, DAN-) autonomic neuropathy and 118 non-diabetic control subjects participated in the study. QT interval was measured on an ECG recorded at rest and QTc calculated according to Bazett's formula. QTc was greater than 0.440 s in 7.6% (95% CI 2.9-12.3) of control subjects, 25.6% (21.0-30.0) of diabetic patients, 30.8% (21.5-40.1) of DAN+, 23.9% (18.9-28.9) of DAN-. QTc was greater than 0.460 s (mean + 2SD of QTc in control subjects) in 11.7% (8.5-14.9) of diabetic patients, 18.1% (10.3-25.9) of DAN+, 9.6% (6.2-13.0) of DAN-. QT was above the 95% upper limit for the control subjects in the plot of measured QT against RR interval in 21.4% (17.3-25.5) of diabetic patients, 26.6% (17.7-35.5) of DAN+, 19.3% (14.7-23.9) of DAN-. No correlation was found between QT interval and age or disease duration. The prevalence of QT prolongation was higher in diabetic patients than in control subjects and in DAN+ than in DAN-.

摘要

评估了意大利皮埃蒙特地区一大群1型糖尿病患者QT间期延长的患病率及其与自主神经病变的关联。379例15至59岁的1型糖尿病患者参与了研究，其中伴有自主神经病变的患者94例（DAN +），不伴有自主神经病变的患者280例（DAN -），另有118名非糖尿病对照者。静息心电图测量QT间期，并根据Bazett公式计算QTc。对照者中QTc大于0.440秒的比例为7.6%（95%CI 2.9 - 12.3），糖尿病患者为25.6%（21.0 - 30.0），DAN +患者为30.8%（21.5 - 40.1），DAN -患者为23.9%（18.9 - 28.9）。糖尿病患者中QTc大于0.460秒（对照者QTc均值 + 2SD）的比例为11.7%（8.5 - 14.9），DAN +患者为18.1%（10.3 - 25.9），DAN -患者为9.6%（6.2 - 13.0）。在测量的QT与RR间期的关系图中，糖尿病患者中QT高于对照者95%上限的比例为21.4%（17.3 - 25.5），DAN +患者为26.6%（17.7 - 35.5），DAN -患者为19.3%（14.7 - 23.9）。未发现QT间期与年龄或病程之间存在相关性。糖尿病患者中QT间期延长的患病率高于对照者，DAN +患者高于DAN -患者。