一种源自人白细胞的嗜中性粒细胞固定因子。I. 生成及部分特性分析。
A neutrophil-immobilizing factor derived from human leukocytes. I. Generation and partial characterization.
作者信息
Goetzl E J, Austen K F
出版信息
J Exp Med. 1972 Dec 1;136(6):1564-80. doi: 10.1084/jem.136.6.1564.
Abstract
A factor has been derived from human leukocytes which irreversibly inhibits the response of human neutrophils to diverse chemotactic stimuli without impairing their viability. It is released by both polymorphonuclear and mononuclear leukocytes during incubation in acidic medium, after endotoxin exposure and subsequent incubation in low potassium medium, and during phagocytosis of particles. It is extractable from both leukocyte types and therefore must be preformed. This chemotactic inhibitor is completely separable from contaminating chemotactic activity in the crude supernatants, has a mol wt of 5000, and is inactivated by digestion with trypsin or chymotrypsin. It has been termed a neutrophil-immobilizing factor because it inhibits neutrophils directly and independently of the chemotactic stimulus, and has relatively little effect on human monocyte chemotaxis.
摘要
已从人白细胞中提取出一种因子，它能不可逆地抑制人中性粒细胞对多种趋化刺激的反应，且不损害其活力。在酸性培养基中孵育、内毒素暴露后再在低钾培养基中孵育以及吞噬颗粒过程中，多形核白细胞和单核白细胞均可释放该因子。它可从这两种白细胞类型中提取出来，因此必定是预先形成的。这种趋化抑制剂在粗制上清液中能与污染的趋化活性完全分离，分子量为5000，用胰蛋白酶或糜蛋白酶消化可使其失活。它被称为中性粒细胞固定因子，因为它直接抑制中性粒细胞，且与趋化刺激无关，对人单核细胞趋化性的影响相对较小。
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J Exp Med. 1972 Dec 1;136(6):1564-80. doi: 10.1084/jem.136.6.1564.
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