Borleffs J C, Schellekens J F, Brouwer E, Rozenberg-Arska M
Department of Internal Medicine, University Hospital Utrecht, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1993 Oct;12(10):772-5. doi: 10.1007/BF02098467.
This report describes two hypogammaglobulinemic patients with persistent Campylobacter jejuni infections in spite of IgG substitution and antibiotic therapy. Since serum bactericidal activity (SBA) depends on IgM, these patients were each treated with six doses of an IgM-containing immunoglobulin preparation (Pentaglobin) at three-week intervals. During IgG therapy SBA was not seen in either patient. However, one hour following administration of the IgM preparation, SBA increased to 90%. Just before the next dose SBA was still at the 30-70% level. Both patients tolerated the therapy very well and there were no culture-confirmed relapses of Campylobacter jejuni infection. The IgM preparation may therefore be a useful alternative to conventional IgG in the treatment of hypogammaglobulinemic patients with persistent Campylobacter jejuni infection.
本报告描述了两名低丙种球蛋白血症患者，尽管接受了IgG替代治疗和抗生素治疗，但仍持续感染空肠弯曲菌。由于血清杀菌活性（SBA）取决于IgM，因此这两名患者均每隔三周接受六剂含IgM的免疫球蛋白制剂（Pentaglobin）治疗。在IgG治疗期间，两名患者均未出现SBA。然而，在给予IgM制剂一小时后，SBA增加至90%。在下一剂之前，SBA仍处于30%-70%的水平。两名患者对治疗耐受性良好，且无空肠弯曲菌感染的培养确诊复发。因此，在治疗持续感染空肠弯曲菌的低丙种球蛋白血症患者时，IgM制剂可能是传统IgG的一种有用替代方案。
