Kerstens P J, Endtz H P, Meis J F, Oyen W J, Koopman R J, van den Broek P J, van der Meer J W
Department of General Internal Medicine, University Hospital Nijmegen, The Netherlands.
Eur J Clin Microbiol Infect Dis. 1992 Sep;11(9):842-7. doi: 10.1007/BF01960888.
Three cases are reported of hypogammaglobulinemic males with recurrent Campylobacter jejuni septicemia and erysipelas-like cellulitis without diarrhoea. In one patient Campylobacter jejuni grew from skin biopsy specimens. The findings in another patient were strongly suggestive of osteomyelitis caused by Campylobacter jejuni. Since the susceptibility of hypogammaglobulinemic patients to infection with Campylobacter jejuni is probably related to a lack of serum bactericidal activity against Campylobacter jejuni due to lack of IgM, two patients in whom previous antimicrobial treatment failed were treated with plasma infusions. This regimen supplemented with imipenem resulted in cure of these relapsing infections. Campylobacter jejuni septicemia must be considered in hypogammaglobulinemic patients who present with periodic fever and cellulitis.
报告了3例低丙种球蛋白血症男性患者，他们反复发生空肠弯曲菌败血症和类丹毒样蜂窝织炎，无腹泻症状。1例患者的皮肤活检标本中培养出空肠弯曲菌。另1例患者的检查结果强烈提示为空肠弯曲菌引起的骨髓炎。由于低丙种球蛋白血症患者对空肠弯曲菌感染的易感性可能与因缺乏IgM而缺乏针对空肠弯曲菌的血清杀菌活性有关，因此对2例先前抗菌治疗失败的患者进行了血浆输注治疗。这种联合亚胺培南的治疗方案治愈了这些复发性感染。对于出现周期性发热和蜂窝织炎的低丙种球蛋白血症患者，必须考虑空肠弯曲菌败血症。
