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[使用噬菌体M13 DNA探针获得的人类“指纹”的家族分析]

[Family analysis of human "fingerprints" obtained using a phage M13 DNA probe].

作者信息

Semina (Barysheva) E V, Bukina A M, Ginter E K, Limborskaia S A

出版信息

Genetika. 1993 Oct;29(10):1608-11.

PMID:8307351
Abstract

The human "fingerprints" detected by the phage M13 DNA probe from 40 simple families with some presumably genetic malformations were observed. When only one parent had a specific band, the mean segregation frequency of all the electrophoretic bands detected was equal to 0.485, which confirmed the hypothesis about the Mendelian inheritance and high level of heterozygosity of hypervariable loci. The mean new measure of similarity between the parents calculated by Li C.C. was 0.54 (this measure within only fathers and only mothers was equal to the mean population level of similarity 0.41).

摘要

利用噬菌体M13 DNA探针,对40个具有一些可能的遗传性畸形的简单家庭进行检测,观察到了人类“指纹”。当只有一方父母有特定条带时,所检测到的所有电泳条带的平均分离频率等于0.485,这证实了关于孟德尔遗传和高变异性位点杂合性水平的假设。李C.C.计算的父母之间相似性的平均新度量为0.54(仅父亲和仅母亲之间的这种度量等于相似性的平均群体水平0.41)。

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