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[触石棉期间触珠蛋白的基因多态性及其水平的定量变化]

[Genetic polymorphism of haptoglobin and quantitative changes in its levels during exposure to asbestos].

作者信息

Afanas'eva I S, Spitsyn V A, Tsurikova G V

出版信息

Genetika. 1993 Nov;29(11):1895-900.

PMID:8307377
Abstract

The polymorphism and serum levels of haptoglobin were studied in asbestosis patients, in the control and the workers exposed to asbest. Hp1-1 has the highest, Hp2-2--the lowest and Hp2-1 has the intermediate concentration of this protein. In the course of contact with asbest, and especially in asbestosis patients, the haptoglobin levels are higher (for all phenotypes). The standard deviation from the Hp concentration in asbestosis patients was significantly higher. The phenotypes Hp1-1 were found more often in asbestosis patients than among asbest-exposed workers.

摘要

对石棉沉着病患者、对照组以及接触石棉的工人的触珠蛋白多态性和血清水平进行了研究。Hp1-1型该蛋白浓度最高,Hp2-2型最低,Hp2-1型居中。在接触石棉的过程中,尤其是石棉沉着病患者,(所有表型的)触珠蛋白水平更高。石棉沉着病患者触珠蛋白浓度的标准差显著更高。Hp1-1型在石棉沉着病患者中比在接触石棉的工人中更常见。

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