Spitsyn V A, Tsurikova G V, Afanas'eva I S
Vestn Ross Akad Med Nauk. 1992(4):46-52.
Genetic polymorphism of the systems of haptoglobin, transferrin, alpha 1-antitrypsin and complement C3 was investigated in patients with asbestosis and in healthy individuals who contacted with asbestos for a long time. The significant differences were discovered between the groups under comparison in the distribution of the phenotypic and genic frequencies in these loci. Simultaneous studies of the levels of these proteins depending on the phenotype demonstrated differentiation of the patients and healthy subjects according to the mean values and dispersions. The data obtained provide evidence in favour of occupational selection as regards the genetic factors investigated.
对石棉沉着病患者以及长期接触石棉的健康个体，研究了触珠蛋白、转铁蛋白、α1 -抗胰蛋白酶和补体C3系统的基因多态性。在这些基因座的表型和基因频率分布方面，所比较的组之间发现了显著差异。根据表型对这些蛋白质水平进行的同步研究表明，患者和健康受试者在平均值和离散度方面存在差异。所获得的数据为所研究的遗传因素在职业选择方面提供了证据支持。
