克罗恩病与重症肌无力：胸腺切除术的潜在作用
Crohn's disease and myasthenia gravis: a possible role for thymectomy.
作者信息
Finnie I A, Shields R, Sutton R, Donnelly R, Morris A I
机构信息
Gastroenterology Unit, Royal Liverpool University Hospital.
出版信息
Gut. 1994 Feb;35(2):278-9. doi: 10.1136/gut.35.2.278.
Abstract
A female patient with a three year history of Crohn's disease of the colon developed myasthenia gravis. Despite diversion of the faecal stream by an ileostomy, and total colectomy, the patient had continuing problems with perineal and perianal abscesses and fistulas. Her myasthenia gravis became unresponsive to anti-cholinergics so a thymectomy was performed. The perineal and perianal disease improved subsequently. This case supports the theory that functional disturbances of the thymus may have a role in the pathogenesis of inflammatory bowel disease.
摘要
一名患有结肠克罗恩病三年的女性患者患上了重症肌无力。尽管通过回肠造口术改道粪便流并进行了全结肠切除术，但患者会阴和肛周脓肿及瘘管问题仍持续存在。她的重症肌无力对抗胆碱能药物不再有反应，因此进行了胸腺切除术。会阴和肛周疾病随后有所改善。该病例支持了胸腺功能紊乱可能在炎症性肠病发病机制中起作用的理论。
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