Piazza M, Chirianni A, Picciotto L, Cataldo P T, Borgia G, Orlando R
Institute of Infectious Diseases, University of Naples 2nd School of Medicine, Italy.
J Med Virol. 1994 Jan;42(1):38-41. doi: 10.1002/jmv.1890420108.
The presence and concentration of haemoglobin in saliva of anti-human immunodeficiency virus (HIV) positive subjects, anti-HIV-negative subjects at high risk of infection, and healthy controls were studied. One hundred eighty-eight subjects were anti-HIV-positive intravenous drug abusers (IVDA), 22 were anti-HIV-positive homosexual men, 23 were anti-HIV-positive heterosexual contacts, 132 were anti-HIV-negative IVDA, 35 were anti-HIV-negative homosexual men, and 154 were healthy controls. Two milliliters of saliva was collected in the morning before brushing teeth, and the presence and the concentration of haemoglobin were determined. Based on hemoglobin, the data show that the anti-HIV-positive IVDA have the highest tendency to bleeding. The difference between this group with respect to anti-HIV-negative IVDA (P < 0.05) and compared with healthy controls (P < 0.01) is statistically significant. This is also true of anti-HIV-positive heterosexual contacts with respect to healthy controls (P < 0.01). Our data show that all at-risk groups, both anti-HIV positive and anti-HIV negative, have higher haemoglobin concentration than the control group; this difference reaches statistical significance only between anti-HIV-positive IVDA and controls (P < 0.01). The concentration of haemoglobin is significantly higher in subjects with CD4+ lymphocytes < 200/mm3 compared to subjects with CD4+ lymphocytes > 200/mm3 (P < 0.01), in subjects with AIDS-related complex (ARC)/AIDS compared to asymptomatic/PGL subjects (P < 0.01), and in subjects with stomatitis compared to subjects without stomatitis (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
研究了抗人类免疫缺陷病毒（HIV）阳性受试者、有高感染风险的抗HIV阴性受试者以及健康对照者唾液中血红蛋白的存在情况和浓度。188名受试者为抗HIV阳性静脉注射吸毒者（IVDA），22名是抗HIV阳性同性恋男性，23名是抗HIV阳性异性接触者，132名是抗HIV阴性IVDA，35名是抗HIV阴性同性恋男性，154名是健康对照者。早晨刷牙前采集2毫升唾液，测定血红蛋白的存在情况和浓度。基于血红蛋白数据显示，抗HIV阳性IVDA出血倾向最高。该组与抗HIV阴性IVDA相比（P<0.05）以及与健康对照相比（P<0.01），差异具有统计学意义。抗HIV阳性异性接触者与健康对照相比也是如此（P<0.01）。我们的数据表明，所有高危组，无论是抗HIV阳性还是抗HIV阴性，血红蛋白浓度均高于对照组；这种差异仅在抗HIV阳性IVDA与对照组之间具有统计学意义（P<0.01）。与CD4+淋巴细胞>200/mm3的受试者相比，CD4+淋巴细胞<200/mm3的受试者血红蛋白浓度显著更高（P<0.01），与无症状/持续性全身性淋巴结肿大（PGL）受试者相比，患有艾滋病相关综合征（ARC）/艾滋病的受试者血红蛋白浓度显著更高（P<0.01），与无口腔炎的受试者相比，患有口腔炎的受试者血红蛋白浓度显著更高（P<0.05）。（摘要截短于250字）
