Richards R M, Xing D K
School of Pharmacy, Robert Gordon University, Aberdeen, Scotland.
J Pharm Sci. 1993 Dec;82(12):1218-20. doi: 10.1002/jps.2600821207.
The in vitro antimicrobial activities of 10 lozenges (Merothol, Merocets, Merocaine, Strepsils (two varieties), Dequacaine, Dequacets, Zensyls, Tyrozets, and Labosept) were determined by use of a microtiter counting method with Streptococcus pyogenes, Staphylococcus aureus, and Candida albicans as the test organisms. Merothol, Merocets, Merocaine, and both Strepsils formulations all reduced the counts of both S. aureus and S. pyogenes suspensions by approximately 6 log cycles within 5 and 20 min, respectively. Merothol, Merocets, and Merocaine also caused a reduction in the counts of the C. albicans suspension approximately 5 log cycles within 40 min, but no other lozenge formulation showed rapid and marked activity against C. albicans. Dequacaine and Dequacets showed marked but much slower activities against this yeast. Zensyls caused an approximately 6-log-cycle reduction in bacterial counts within 40 min, and Dequacaine, Dequacets, and Tyrozets showed marked but slower antibacterial activities. This work confirmed by a statistically sound in vitro method the in vivo antibacterial activities reported for Merothol, Merocets, and Merocaine, demonstrated equivalent antibacterial activities for Strepsils, and indicated that Merothol, Merocets, and Merocaine also showed marked activities against C. albicans.
采用微量滴定计数法，以化脓性链球菌、金黄色葡萄球菌和白色念珠菌为受试微生物，测定了10种含片（美索洛尔、美洛西酯、美洛卡因、喉糖（两种变体）、地夸卡因、地夸西酯、锌酰氯、酪氨酸酯和拉波塞普）的体外抗菌活性。美索洛尔、美洛西酯、美洛卡因以及两种喉糖制剂分别在5分钟和20分钟内使金黄色葡萄球菌和化脓性链球菌悬液的菌数减少了约6个对数周期。美索洛尔、美洛西酯和美洛卡因还在40分钟内使白色念珠菌悬液的菌数减少了约5个对数周期，但没有其他含片制剂对白色念珠菌表现出快速且显著的活性。地夸卡因和地夸西酯对这种酵母菌表现出显著但慢得多的活性。锌酰氯在40分钟内使细菌菌数减少了约6个对数周期，地夸卡因、地夸西酯和酪氨酸酯表现出显著但较慢的抗菌活性。这项工作通过统计学可靠的体外方法证实了美索洛尔、美洛西酯和美洛卡因体内抗菌活性的报道，证明了喉糖具有同等抗菌活性，并表明美索洛尔、美洛西酯和美洛卡因对白色念珠菌也表现出显著活性。
