Davis C A, Driscoll D J, Perrault J, Greenwood D H, Schaff H V, Puga F J, Danielson G K, Feldt R H
Mayo Medical School, Mayo Clinic Rochester, MN 55905.
Mayo Clin Proc. 1994 Feb;69(2):112-4. doi: 10.1016/s0025-6196(12)61035-0.
The current study was undertaken to assess the frequency of excessive enteric protein loss and protein-losing enteropathy in the relatively early period after the Fontan operation.
Protein excretion was determined in 26 of 27 consecutive patients who underwent the Fontan procedure between January and June 1990 at the Mayo Clinic.
At two testing intervals during the first 4 months after the Fontan operation, alpha 1-antitrypsin clearance and fecal alpha 1-antitrypsin concentration studies were done.
All results were normal for the first postoperative test period (2 to 8 weeks). For the second study period, all 17 patients tested had normal alpha 1-antitrypsin clearances. One of the 17 patients had an appreciably increased fecal alpha 1-antitrypsin concentration and transient protein-losing enteropathy.
Excessive enteric protein loss and protein-losing enteropathy are relatively uncommon during the first 4 months after the Fontan operation.
本研究旨在评估在Fontan手术相对早期阶段肠道蛋白过度丢失和蛋白丢失性肠病的发生率。
对1990年1月至6月在梅奥诊所接受Fontan手术的连续27例患者中的26例进行了蛋白质排泄测定。
在Fontan手术后的前4个月内的两个测试间隔期，进行了α1-抗胰蛋白酶清除率和粪便α1-抗胰蛋白酶浓度研究。
术后第一个测试期（2至8周）所有结果均正常。在第二个研究期，接受测试的17例患者的α1-抗胰蛋白酶清除率均正常。17例患者中有1例粪便α1-抗胰蛋白酶浓度明显升高，并出现短暂的蛋白丢失性肠病。
在Fontan手术后的前4个月内，肠道蛋白过度丢失和蛋白丢失性肠病相对不常见。
