Kelly A M, Feldt R H, Driscoll D J, Danielson G K
Department of Pediatric and Adolescent Medicine, Mayo Clinic Rochester, Minnesota 55905, USA.
Mayo Clin Proc. 1998 Aug;73(8):777-9. doi: 10.4065/73.8.777.
Protein-losing enteropathy (PLE) is a serious complication of the Fontan operation and is associated with pronounced mortality. Medical management of PLE has been only partially successful. A recent report noted dramatic improvement in patients with PLE within 3 weeks of subcutaneous administration of heparin. We report a case of reversal of PLE with resolution of clinical symptoms and normalization of serum albumin, total protein, and fecal alpha1-antitrypsin values after several months of heparin treatment. Our findings substantiate those recently reported but suggest that reversal of PLE may necessitate more than a few weeks of heparin therapy.
蛋白丢失性肠病（PLE）是Fontan手术的一种严重并发症，与显著的死亡率相关。PLE的药物治疗仅取得了部分成功。最近的一份报告指出，皮下注射肝素3周内，PLE患者有显著改善。我们报告了1例经肝素治疗数月后PLE逆转的病例，临床症状消失，血清白蛋白、总蛋白和粪便α1-抗胰蛋白酶值恢复正常。我们的研究结果证实了最近报道的结果，但表明PLE的逆转可能需要超过几周的肝素治疗。
