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[近平滑念珠菌与生殖器官感染]

[Candida parapsilosis in reproductive organ infections].

作者信息

Pawlik B, Filip E

机构信息

Zakład Mykologii Instytutu Mikrobiologii AM w Krakowie.

出版信息

Med Dosw Mikrobiol. 1993;45(2):249-52.

PMID:8309308
Abstract

Frequency of occurrence of strains of C. parapsilosis, their susceptibility to drugs and importance in pathogenesis of vaginal mycosis, was evaluated. Strains of C. parapsilosis were isolated in 44 cases which comprises 1.34% of a total number of 3275 tested Candida-like strains. Vaginal mycoses occurred in presence of Lactobacillus sp., normal pH values of vaginal contents, whereas leukocytosis was differing. Following drugs were used for testing susceptibility of C. parapsilosis: nystatin, pimaricin, amphotericin B, flucytosine, cotrimoxazole, miconazole, ketoconazole, tioconazole, fluconazole and itraconazole. It has been demonstrated that 38.3% strains of C. parapsilosis were exhibiting lowered activity toward amphotericin B, nystatin (23.5% resistant) and flucytosine (11.7% resistant). Tested strains were susceptible to remaining drugs within 94.1% and 100%.

摘要

评估了近平滑念珠菌菌株的出现频率、它们对药物的敏感性以及在阴道真菌病发病机制中的重要性。在44例病例中分离出近平滑念珠菌菌株,占3275株测试念珠菌样菌株总数的1.34%。阴道真菌病在存在乳酸杆菌属、阴道内容物pH值正常的情况下发生,而白细胞增多情况各异。使用以下药物测试近平滑念珠菌的敏感性:制霉菌素、匹马霉素、两性霉素B、氟胞嘧啶、复方新诺明、咪康唑、酮康唑、噻康唑、氟康唑和伊曲康唑。已证明38.3%的近平滑念珠菌菌株对两性霉素B、制霉菌素(23.5%耐药)和氟胞嘧啶(11.7%耐药)的活性降低。测试菌株对其余药物的敏感性在94.1%至100%之间。

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