Carrillo-Muñoz Alfonso Javier, Tur-Tur Cristina, Cárdenes Delia, Rojas Florencia, Giusiano Gustavo
Departamento de Microbiología, ACIAM, Barcelona, España.
Rev Iberoam Micol. 2013 Apr-Jun;30(2):130-3. doi: 10.1016/j.riam.2012.12.002. Epub 2013 Jan 11.
Dermatophytes can be divided into geophilic (soil), zoophilic (animals) and anthropophilic (humans) strains, depending on the source of the keratin that they use for nutritional purposes.
The in vitro susceptibility of clinical isolates of dermatophyte fungi has been studied in the 3 ecological groups with several antifungal agents for the topical management of dermatophytoses in order to determine their relationship with the ecological group.
A standardised dilution micromethod in a liquid medium was used for the determination of the in vitro antifungal activity of 9 topical antifungal drugs: amorolfine (AMR), bifonazole (BFZ), clotrimazole, econazole, ketoconazole, miconazole, oxiconazole, terbinafine (TRB) and tioconazole. The in vitro activity was obtained against 124 clinical isolates of dermatophyte moulds from the anthropophilic, zoophilic and geophilic ecological groups.
The in vitro antifungal activity was different depending on the ecological group, although a species-dependent profile was also observed.
Azole derivatives showed a similar antifungal profile, being more active against anthropophilic dermatophytes > zoophilic > geophilic. Activity of TRB and AMR was different from that of azole derivatives (zoophilic > anthropophilic > geophilic). A higher in vitro antifungal activity against the 3 ecological groups was observed with TRB and AMR, whilst BFZ was the less active drug.
皮肤癣菌可根据其用于营养目的的角蛋白来源分为嗜土性（土壤）、嗜动物性（动物）和嗜人性（人类）菌株。
研究了皮肤癣菌临床分离株在3个生态组中对几种抗真菌药物的体外敏感性，用于皮肤癣菌病的局部治疗，以确定它们与生态组的关系。
采用液体培养基中的标准化稀释微量法测定9种局部抗真菌药物的体外抗真菌活性：阿莫罗芬（AMR）、联苯苄唑（BFZ）、克霉唑、益康唑、酮康唑、咪康唑、奥昔康唑、特比萘芬（TRB）和噻康唑。针对来自嗜人性、嗜动物性和嗜土性生态组的124株皮肤癣菌临床分离株获得了体外活性。
体外抗真菌活性因生态组而异，尽管也观察到了种属依赖性特征。
唑类衍生物显示出相似的抗真菌谱，对嗜人性皮肤癣菌的活性更强>嗜动物性>嗜土性。TRB和AMR的活性与唑类衍生物不同（嗜动物性>嗜人性>嗜土性）。TRB和AMR对3个生态组的体外抗真菌活性更高，而BFZ是活性最低的药物。
