Lukas S E, Dobrosielski M, Chiu T M, Woods B T, Teoh S K, Mendelson J H
Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, Belmont, MA 02178.
Pharmacol Biochem Behav. 1993 Dec;46(4):781-5. doi: 10.1016/0091-3057(93)90201-4.
A nonferrous joystick device was developed to permit subjects to continuously report ethanol-induced alterations in subjective mood states while undergoing a magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) procedure. The device utilizes air pressure (supplied by a small compressor) that is directed to a series of tubes that terminate in a hand-held unit. The hand-held unit easily fits inside the magnet and resembles a standard computer game joystick except that the ends of the air hoses replace the buttons. The control unit contains three pressure transducers, which are triggered when the tubes are occluded by the subject, activating different pens on an event marker located 6 m from the whole body imager. The unit is safe to use inside a 1.5-Tesla magnetic field and does not disrupt the MRI and MRS recording procedures. Subjective reports of ethanol-induced euphoria and intoxication paralleled the MRS detection of ethanol in the brain. This device could prove to be useful in numerous behavioral studies involving whole-body MRI and MRS.
开发了一种有色金属操纵杆装置，以便让受试者在接受磁共振成像（MRI）和磁共振波谱（MRS）检查过程中，能够持续报告乙醇引起的主观情绪状态变化。该装置利用由小型压缩机提供的气压，气压被导向一系列终止于手持单元的管道。手持单元很容易放入磁体内部，它类似于标准的电脑游戏操纵杆，只是空气软管的末端取代了按钮。控制单元包含三个压力传感器，当管道被受试者堵塞时会被触发，从而激活位于距全身成像仪6米处的事件标记器上的不同记录笔。该装置在1.5特斯拉磁场内使用是安全的，并且不会干扰MRI和MRS记录程序。乙醇引起的欣快感和中毒的主观报告与MRS对大脑中乙醇的检测结果相平行。这种装置可能在涉及全身MRI和MRS的众多行为研究中被证明是有用的。
