使用针对WC1、TCR1和BoCD3的单克隆抗体对包括肠道相关淋巴组织的牛小肠进行免疫组织学研究。
Immunohistological study on bovine small intestine including gut associated lymphoid tissue using monoclonal antibodies to WC1, TCR1 and BoCD3.
作者信息
Okada K, Suzuki K, Murakami K, Davis W C
机构信息
Department of Veterinary Pathology, Faculty of Agriculture, Iwate University, Japan.
出版信息
Vet Immunol Immunopathol. 1993 Nov;39(1-3):169-75. doi: 10.1016/0165-2427(93)90178-7.
Selected antibodies (mAbs) that clustered in temporary cluster TC22 (WC1) and TC36 (TCR1) and one unclustered mAb thought to detect BoCD3 were used to compare the distribution of T and B cells and subpopulations of WC1+ or TCR1+ cells in fetal, calf, and young adult gut associated lymphoid tissue. Cells putatively positive for BoCD3 (MM1A) were detected in the interfollicular tissue similar to the pattern noted for BoCD2+ or BoCD5+ cells. WC1+ or TCR1+ cells were detected in small numbers in follicles and interfollicular tissue. Numerous WC1+ or TCR1+ cells were evident in the lamina propria and epithelia, with the highest frequency evident in tissues from animals 8 months of age.
选择聚集在临时簇TC22（WC1）和TC36（TCR1）中的抗体（单克隆抗体）以及一种被认为可检测牛CD3的未聚集单克隆抗体，用于比较胎儿、小牛和年轻成年动物肠道相关淋巴组织中T细胞和B细胞的分布以及WC1 +或TCR1 +细胞亚群的分布。在滤泡间组织中检测到推定的牛CD3（MM1A）阳性细胞，其模式与牛CD2 +或牛CD5 +细胞相似。在滤泡和滤泡间组织中少量检测到WC1 +或TCR1 +细胞。在固有层和上皮中可见大量WC1 +或TCRI +细胞，在8月龄动物的组织中频率最高。
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