Iwamoto N, Ishihara T, Ito H, Uchino F
Department of Neurosurgery, Yamaguchi University School of Medicine, Japan.
Acta Neuropathol. 1993;86(5):418-21. doi: 10.1007/BF00228574.
To investigate the relationship between cerebral amyloid angiopathy and subcortical (lobar) hemorrhage, we examined the severity of amyloid deposition in the leptomeningeal, cortical and subcortical arteries in 28 autopsied elderly patients with cerebral amyloid angiopathy with subcortical hemorrhage, deep cerebral hemorrhage or without hemorrhage. The severity was evaluated in terms of the frequency of amyloid-laden arteries and the degree of amyloid deposition within the arteries. The frequency of amyloid-laden arteries, especially among arteries over 200 microns in diameter, was higher in subcortical hemorrhage group than in the deep hemorrhage group and the non-hemorrhage group, and when the degree of amyloid deposition in the arteries was divided into four grades (none, mild, moderate or severe), the severity was higher in the subcortical hemorrhage group than in the deep cerebral hemorrhage group and the non-hemorrhage group. These results suggest that severe cerebral amyloid angiopathy is related to non-traumatic subcortical hemorrhage in elderly persons.
为了研究脑淀粉样血管病与皮质下（脑叶）出血之间的关系，我们检查了28例患有脑淀粉样血管病且伴有皮质下出血、深部脑出血或无出血的老年尸检患者软脑膜、皮质和皮质下动脉中淀粉样蛋白沉积的严重程度。根据载淀粉样蛋白动脉的频率和动脉内淀粉样蛋白沉积的程度对严重程度进行评估。载淀粉样蛋白动脉的频率，尤其是直径超过200微米的动脉，在皮质下出血组中高于深部出血组和无出血组，并且当动脉内淀粉样蛋白沉积程度分为四个等级（无、轻度、中度或重度）时，皮质下出血组的严重程度高于深部脑出血组和无出血组。这些结果表明，严重的脑淀粉样血管病与老年人非创伤性皮质下出血有关。
