Mountjoy C Q, Tomlinson B E, Gibson P H
J Neurol Sci. 1982 Nov-Dec;57(1):89-103. doi: 10.1016/0022-510x(82)90113-7.
The possibility of a direct association between the amyloid in senile plaques and in cerebral blood vessels was tested by a quantitative analysis of amyloid in these sites in the autopsy brains of 15 patients suffering from senile dementia of Alzheimer type and 30 non-demented old subjects. The numbers and severity of involvement of vessels showing amyloid were expressed as a vascular 'amyloid score'. Over all the cases amyloid within vessels was found to increase with each decade but no direct correlation existed between age and amyloid scores. Plaques were found in the absence of vascular amyloid and in 2 cases, vascular amyloid occurred without plaque formation. Nevertheless, there was a statistically significant association between the presence of vascular amyloid and of plaques and a significant correlation between total amyloid scores and plaque counts in the temporal lobe of demented subjects. However, amyloid scores only explained about 30% of the variance in plaque counts and amyloid in vessels is unlikely to contribute to the development of all senile plaques. There was no significant correlation between the amount of vascular amyloid observed and the clinical severity of the dementia.
通过对15例阿尔茨海默型老年痴呆患者和30例非痴呆老年受试者尸检大脑中这些部位的淀粉样蛋白进行定量分析，来检测老年斑和脑血管中的淀粉样蛋白之间直接关联的可能性。显示淀粉样蛋白的血管受累数量和严重程度用血管“淀粉样蛋白评分”表示。在所有病例中，血管内淀粉样蛋白随每十年增加，但年龄与淀粉样蛋白评分之间不存在直接相关性。在没有血管淀粉样蛋白的情况下发现了斑块，并且在2例病例中，血管淀粉样蛋白在没有斑块形成的情况下出现。然而，血管淀粉样蛋白和斑块的存在之间存在统计学上的显著关联，并且痴呆受试者颞叶中的总淀粉样蛋白评分与斑块计数之间存在显著相关性。然而，淀粉样蛋白评分仅解释了斑块计数差异的约30%，血管中的淀粉样蛋白不太可能导致所有老年斑的形成。观察到的血管淀粉样蛋白量与痴呆的临床严重程度之间没有显著相关性。
