Agerholm J S, Basse A, Christensen K
Department of Pathology and Epidemiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Acta Vet Scand. 1993;34(3):245-53. doi: 10.1186/BF03548188.
The methods of the Danish Bovine Genetic Disease Programme are outlined, and the results obtained during the first 3 years in function are described. The most common disease reported was spinal muscular atrophy in calves of the Red Danish Dairy breed with 312 reports. Necropsy was performed on 162 cases, and spinal muscular atrophy was diagnosed in 82 of these. Bovine progressive degenerative myeloencephalopathy, rectovaginal constriction, syndrome of arthrogryposis and palatoschisis, hereditary chondrodysplasia (2 different types), syndactylism, epitheliogenesis imperfecta, and osteogenesis imperfecta was diagnosed with 1 case each. Lethal trait A46 was diagnosed in 4 calves. Some of these diseases have not previously been described in Denmark, and epitheliogenesis imperfecta was for the first time diagnosed in the Hereford breed. Chromosome translocation 1/29 was detected in the Blonde d'Aquitaine (BAQ), Limousine, and Red Danish Dairy breed. The aberration occurred frequently in BAQ. Furthermore, a complex chromosome translocation t(1;8;9)(q45;q13;q26) was detected in the Red Danish Dairy breed.
概述了丹麦牛遗传疾病计划的方法，并描述了该计划运行头3年所取得的成果。报告的最常见疾病是丹麦红牛犊牛的脊髓性肌萎缩症，共报告了312例。对162例进行了尸检，其中82例被诊断为脊髓性肌萎缩症。牛进行性退行性脊髓脑病、直肠阴道狭窄、关节弯曲和腭裂综合征、遗传性软骨发育不良（2种不同类型）、并指畸形、上皮生成不全和成骨不全各诊断出1例。在4头犊牛中诊断出致死性状A46。其中一些疾病此前在丹麦未曾有过描述，上皮生成不全首次在赫里福德品种中被诊断出。在阿基坦棕牛（BAQ）、利木赞牛和丹麦红牛品种中检测到染色体易位1/29。这种畸变在阿基坦棕牛中频繁出现。此外，在丹麦红牛品种中检测到一种复杂的染色体易位t(1;8;9)(q45;q13;q26)。
