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丹麦荷斯坦-弗里生牛的牛白细胞黏附缺陷。I. PCR筛查及等位基因频率估计

Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. I. PCR screening and allele frequency estimation.

作者信息

Jørgensen C B, Agerholm J S, Pedersen J, Thomsen P D

机构信息

Department of Animal Science and Animal Health, Royal Veterinary and Agricultural University, Copenhagen, Denmark.

出版信息

Acta Vet Scand. 1993;34(3):231-6. doi: 10.1186/BF03548186.

DOI:10.1186/BF03548186
PMID:7906090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8112504/
Abstract

A screening program for bovine leukocyte adhesion deficiency (BLAD) in Danish Holstein-Friesian cattle has been initiated. During the first months 1611 animals were tested by a PCR based assay. Of these animals 1256, 346, and 8 were assigned normal, BLAD carriers, and BLAD affected animals, respectively. One bull, born as a co-twin, showed weak reaction for the BLAD allele on DNA isolated from leukocytes, but a normal genotype on DNA isolated from semen. Chromosome analysis showed that this bull was a blood chimaera. Estimation of the BLAD allele frequency upon the PCR test results showed that around 450 Danish calves born in 1991 might have been affected with the recessive disorder.

摘要

丹麦荷斯坦-弗里生奶牛的牛白细胞黏附缺陷症（BLAD）筛查项目已经启动。在最初的几个月里，通过基于聚合酶链反应（PCR）的检测方法对1611头动物进行了检测。在这些动物中，分别有1256头、346头和8头被判定为正常、携带BLAD基因以及受BLAD影响的动物。一头作为双生牛出生的公牛，从白细胞分离的DNA上对BLAD等位基因显示出微弱反应，但从精液分离的DNA上基因型正常。染色体分析表明这头公牛是血液嵌合体。根据PCR检测结果估算BLAD等位基因频率显示，1991年出生的约450头丹麦犊牛可能受到了这种隐性疾病的影响。

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本文引用的文献

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2
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J Am Vet Med Assoc. 1983 Nov 15;183(10):1093-4.
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Bovine granulocytopathy syndrome of Holstein-Friesian calves and heifers.荷斯坦-弗里生犊牛和小母牛的牛粒细胞病综合征
Nihon Juigaku Zasshi. 1987 Aug;49(4):733-6. doi: 10.1292/jvms1939.49.733.
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Bovine granulocytopathy syndrome: neutrophil dysfunction in Holstein Friesian calves.牛粒细胞病综合征：荷斯坦弗里生犊牛的中性粒细胞功能障碍
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Nucleic Acids Res. 1989 Oct 25;17(20):8390. doi: 10.1093/nar/17.20.8390.
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Am J Vet Res. 1990 Nov;51(11):1826-36.
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