Abernethy D R
Brown University, Department of Medicine, Rhode Island Hospital, Providence 02903.
Am J Cardiol. 1994 Jan 27;73(3):10A-17A. doi: 10.1016/0002-9149(94)90269-0.
Pharmacokinetic and pharmacodynamic data were compared between elderly and young patients with hypertension who received single intravenous doses of amlodipine, a dihydropyridine calcium antagonist, followed by oral administration of amlodipine up to 10 mg once daily for 12 weeks. After intravenous administration, elderly patients had prolonged elimination half-life values (58 +/- 11 vs 42 +/- 8 hr; p < 0.05) caused by decreased clearance (19 +/- 5 vs 7 liters/hr; p < 0.05). Systolic and diastolic blood pressures were significantly decreased from baseline throughout the 3-month treatment period in both groups. After long-term oral administration, elderly and young patients had comparable decreases in mean blood pressure at a given drug plasma concentration. The antihypertensive effect of amlodipine is well correlated with plasma concentration and, at a given concentration, is similar in both elderly and young patients.
对接受单剂量静脉注射氨氯地平（一种二氢吡啶类钙拮抗剂）的老年和年轻高血压患者的药代动力学和药效学数据进行了比较，随后口服氨氯地平，每日一次，剂量高达10mg，持续12周。静脉给药后，老年患者的消除半衰期延长（58±11对42±8小时；p<0.05），这是由于清除率降低（19±5对7升/小时；p<0.05）。在整个3个月的治疗期间，两组的收缩压和舒张压均较基线显著降低。长期口服给药后，在给定的药物血浆浓度下，老年和年轻患者的平均血压下降幅度相当。氨氯地平的降压作用与血浆浓度密切相关，在给定浓度下，老年和年轻患者相似。
