Bortolotto L A, Silva H B, Galvão L F, Veloso L G, Barretto A C, Belloti G, Pileggi F
Instituto do Coração do Hospital das Clínicas, FMUSP.
Arq Bras Cardiol. 1993 Apr;60(4):243-5.
To evaluate the role of arterial hypertension (AH) in the development of proteinuria in patients with decompensated congestive heart failure (CHF).
Twenty-four-hour urinary protein determinations were obtained from 30 patients with decompensated CHF, before and after therapy of CHF. The patients were divided in two groups according with the presence of AH as cause of CHF: group A, 18 patients with CHF due to AH and group B, 12 patients with CHF due to idiopathic dilated or chagasic cardiomyopathy without previous AH.
There was no differences between the groups concerning age, sex, renal function and duration of CHF. Before treatment, 88% of group A presented proteinuria exceeding 150 mg/24h compared to 25% of group B (p < 0.01). After treatment of CHF, proteinuria > 150 mg/24 h remained in 38% of group A and in none of group B. Proteinuria did not reverse after 6 months of follow-up in 2 patients, one of them showed benign nephrosclerosis in renal biopsy.
Patients with decompensated CHF, unrelated to AH, presented mild proteinuria reversible after the treatment, that improved renal function. In patients with CHF due to AH, proteinuria was more frequent, more severe and did not improve after the treatment, suggesting renal lesion.
评估动脉高血压(AH)在失代偿性充血性心力衰竭(CHF)患者蛋白尿发生中的作用。
对30例失代偿性CHF患者在CHF治疗前后进行24小时尿蛋白测定。根据AH是否为CHF病因将患者分为两组:A组,18例因AH导致CHF的患者;B组,12例因特发性扩张型或恰加斯心肌病导致CHF且既往无AH的患者。
两组在年龄、性别、肾功能和CHF病程方面无差异。治疗前,A组88%的患者蛋白尿超过150mg/24小时,而B组为25%(p<0.01)。CHF治疗后,A组38%的患者蛋白尿>150mg/24小时,而B组无一例出现。2例患者随访6个月后蛋白尿未逆转,其中1例肾活检显示良性肾硬化。
与AH无关的失代偿性CHF患者出现轻度蛋白尿,治疗后可逆转,肾功能得到改善。因AH导致CHF的患者蛋白尿更常见、更严重,治疗后无改善,提示存在肾脏病变。