Uehira M, Matsuda H, Hikita I, Sakata T, Fujiwara H, Nishimoto H
Shionogi Research Laboratories, Shionogi & Co., Ltd, Osaka, Japan.
Int Immunol. 1993 Dec;5(12):1619-27. doi: 10.1093/intimm/5.12.1619.
Transgenic mice constitutively expressing IL-7 developed severe dermatitis with erythroderma and alopecia. The skin lesions were characterized by massive infiltration of mononuclear cells. Immunofluorescence staining showed that most of the infiltrating cells were T cells with the majority bearing the gamma delta TCR other than the V gamma 5 moiety. Furthermore, the number of gamma delta T cells had increased in the lymphoid organs of the dermatitis animals. These findings indicate the strong relationship between the expression of IL-7 and the development of gamma delta T cells in vivo and the pathological involvement of proliferated and/or activated gamma delta T cells in skin disease.
持续表达白细胞介素-7的转基因小鼠出现了伴有红皮病和脱发的严重皮炎。皮肤损伤的特征是单核细胞大量浸润。免疫荧光染色显示，大多数浸润细胞是T细胞，其中大多数携带γδT细胞受体而非Vγ5部分。此外，皮炎动物淋巴器官中的γδT细胞数量增加。这些发现表明白细胞介素-7的表达与体内γδT细胞的发育之间存在密切关系，以及增殖和/或活化的γδT细胞在皮肤病中的病理参与。
