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非酶促转化在雄激素向雌激素生物合成过程中的参与。

Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens.

作者信息

Goto J, Fishman J

出版信息

Science. 1977 Jan 7;195(4273):80-1. doi: 10.1126/science.831259.

DOI:10.1126/science.831259
PMID:831259
Abstract

The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2 beta position, and the product rapidly and nonenzymatically collapses to an estrogen.

摘要

雄激素生物合成雌激素的过程通过三步酶促羟基化反应进行，其中前两步发生在C-19甲基上并将其转化为醛。最后一步也是限速羟基化反应发生在2β位，产物迅速且非酶促地转化为雌激素。

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Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens.非酶促转化在雄激素向雌激素生物合成过程中的参与。
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