人体对口服8-甲氧基补骨脂素光敏性的多色作用光谱。

A polychromatic action spectrum for photosensitivity to orally administered 8-methoxypsoralen in humans.

作者信息

Bech-Thomsen N, Wulf H C

机构信息

Department of Dermatology, Copenhagen University Hospital, Rigshospitalet, Denmark.

出版信息

Clin Exp Dermatol. 1994 Jan;19(1):12-5. doi: 10.1111/j.1365-2230.1994.tb01107.x.

DOI:10.1111/j.1365-2230.1994.tb01107.x

PMID:8313631

Abstract

The action spectrum for producing minimal phototoxic erythema after oral administration of 8-methoxypsoralen (8-MOP) was determined in the range of 312-368 nm in 12 human volunteers using six different UV radiation sources. The peak sensitivity was found to be at 343 nm. The 8-MOP photosensitivity was at a high level (> or = 0.75 of maximum) between 336 and 355 nm. Conventional UVA radiation sources, like the Philips TL/09R tube, have a high energy output within 335 and 355 nm, and are therefore highly recommended in oral psoralen plus UVA radiation treatment.

摘要

在12名人类志愿者中，使用六种不同的紫外线辐射源，测定了口服8-甲氧基补骨脂素（8-MOP）后产生最小光毒性红斑的作用光谱，范围为312-368nm。发现峰值敏感性在343nm处。8-MOP的光敏性在336至355nm之间处于高水平（≥最大值的0.75）。传统的UVA辐射源，如飞利浦TL/09R灯管，在335至355nm范围内具有高能量输出，因此在口服补骨脂素加UVA辐射治疗中强烈推荐使用。