Aly R, Bayles C I, Oakes R A, Bibel D J, Maibach H I
Department of Dermatology, University of California at San Francisco 94143-0536.
Clin Exp Dermatol. 1994 Jan;19(1):43-6. doi: 10.1111/j.1365-2230.1994.tb01113.x.
Whether griseofulvin, which pioneered oral antifungal therapy, works topically has long been an open question. The effectiveness of a 1% griseofulvin spray formulation and the vehicle alone against experimentally induced Trichophyton mentagrophytes lesions on the forearms of 16 healthy volunteers and in the treatment of 100 tinea pedis patients (various dermatophytes) was evaluated in a double-blind study. After treatment of the 58 induced lesions twice daily for 14 days with topical griseofulvin (28) or placebo (30), 89% of lesions receiving griseofulvin were mycologically negative compared with 30% in the placebo group (P < 0.0001). In the tinea pedis patients who applied medication once daily for 4 weeks the mycological cure was 79.2% on the fourth week and 80.9% 2 weeks post-treatment. Resurgence of dermatophytes quickly followed the end of treatment in the placebo group only, which had a mycological cure rate of 34% (week 6). Administration of a topical formulation of griseofulvin thus may be an effective treatment for interdigital dermatophyte infections.
开创口服抗真菌疗法的灰黄霉素是否具有局部疗效，长期以来一直是个悬而未决的问题。在一项双盲研究中，评估了1%灰黄霉素喷雾制剂以及单独的赋形剂对16名健康志愿者前臂上实验性诱发的须癣毛癣菌损伤以及100名足癣患者（多种皮肤癣菌）的治疗效果。在用局部灰黄霉素（28例）或安慰剂（30例）每日两次治疗58处诱发损伤14天后，接受灰黄霉素治疗的损伤中89%真菌学检查呈阴性，而安慰剂组为30%（P<0.0001）。在足癣患者中，每日用药一次，持续4周，第4周时真菌学治愈率为79.2%，治疗后2周为80.9%。仅在安慰剂组中，治疗结束后皮肤癣菌迅速复发，其真菌学治愈率为34%（第6周）。因此，局部应用灰黄霉素制剂可能是治疗指间皮肤癣菌感染的有效方法。
