Van Eerdewegh P, Hampe C L, Suarez B K, Reich T
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Genet Epidemiol. 1993;10(6):395-400. doi: 10.1002/gepi.1370100611.
The evidence for linkage between Alzheimer's disease and markers on both chromosomes 19 and 21 [Pericak-Vance et al., 1991] by the affected-pedigree-member (APM) method [Weeks and Lange, 1988] cannot be replicated on any of the available GAW8 data sets when marker allele frequencies are estimated from the combined sample. The strong dependence of the APM method on accurate estimation of marker allele frequencies, and the effects of noninformative pairs and of genetic distance in informative pairs of relatives are illustrated.
采用患病家系成员（APM）法[威克斯和兰格，1988]得出的阿尔茨海默病与19号和21号染色体上的标记之间存在连锁关系的证据[佩里卡克 - 万斯等人，1991]，当从合并样本中估计标记等位基因频率时，在任何可用的GAW8数据集上均无法复制。文中说明了APM方法对标记等位基因频率准确估计的强烈依赖性，以及无信息亲属对和有信息亲属对中遗传距离的影响。
