通过患病家系成员法进行连锁检测：究竟检测的是什么？
Linkage detection by the Affected-Pedigree-Member method: what is really tested?
作者信息
Babron M C, Martinez M, Bonaïti-Pellié C, Clerget-Darpoux F
机构信息
INSERM, Unité 155, Paris, France.
出版信息
Genet Epidemiol. 1993;10(6):389-94. doi: 10.1002/gepi.1370100610.
PMID:8314032
Abstract
We show that the null hypothesis in the Affected-Pedigree-Member (APM) method is composed of two sub-hypotheses: no linkage and correct marker allele distribution. As a result, the APM method is not robust to misspecification of marker allele frequencies.
摘要
我们表明，患病家系成员（APM）方法中的零假设由两个子假设组成：无连锁和正确的标记等位基因分布。因此，APM方法对于标记等位基因频率的错误设定并不稳健。
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