Austin M A
Department of Epidemiology, University of Washington, Seattle 98195.
Genet Epidemiol. 1993;10(6):519-22. doi: 10.1002/gepi.1370100631.
The Kaiser-Permanente Women Twins Study began with the establishment of a large registry of twins at Kaiser-Permanente, a managed health care program in Oakland, California. In 1978-79, 434 pairs of women twins, 255 monozygotic and 179 dizygotic, with average age 41 years, were recruited from this registry for a study of coronary heart disease risk factors. Previous analyses of these data have shown moderate heritability for blood pressure and high heritability for lipids, even after adjustment for differential environmental covariance between twin types. For GAW8, the data provided included age, race, weight, height, blood pressure, lipids, smoking, alcohol consumption, exercise, degree of contact between co-twins, menstrual status, and medication for hypertension. Exam 2 of this cohort was completed in 1989-90 and has recently reported nearly complete heritability for lipoprotein(a).
凯撒-永久女性双胞胎研究始于在加利福尼亚州奥克兰的一个管理式医疗保健项目凯撒-永久建立一个大型双胞胎登记处。1978 - 1979年,从这个登记处招募了434对女性双胞胎,其中255对为同卵双胞胎,179对为异卵双胞胎,平均年龄41岁,用于一项冠心病危险因素研究。此前对这些数据的分析表明,即使在对双胞胎类型之间的差异环境协方差进行调整之后,血压的遗传度为中等,而血脂的遗传度较高。对于GAW8,提供的数据包括年龄、种族、体重、身高、血压、血脂、吸烟、饮酒、运动、双胞胎之间的接触程度、月经状况以及高血压用药情况。该队列的第二次检查于1989 - 1990年完成,最近报告了脂蛋白(a)几乎完全的遗传度。