Bray G A, Benfield J R
Am J Clin Nutr. 1977 Jan;30(1):121-7. doi: 10.1093/ajcn/30.1.121.
Intestinal bypass for obesity can be justified only if the risks of excess weight are higher than those of the surgery. Indications for this surgery need to be carefully defined and the patient and family should clearly understand the potential risks and benefits. Weight loss results from a decrease in food intake, altered taste preferences, and malabsorption. The benefits of this treatment are permanent weight loss, improved psychosocial function, and a reduction in medical morbidity. The potential risks consist of mortality, a variety of postoperative complications, liver failure, renal stones, and the consequences of bacterial overgrowth in the defunctionalized bowel. This operation trades the consequences of a short bowel for obesity and should only be undertaken where a skilled team of surgeons, internists, and psychiatrists are available and able to provide the necessary preoperative and postoperative managements.
只有当超重风险高于手术风险时,肠道旁路手术治疗肥胖才是合理的。该手术的适应症需要仔细界定,患者及其家属应清楚了解潜在的风险和益处。体重减轻源于食物摄入量减少、味觉偏好改变和吸收不良。这种治疗的益处包括永久性体重减轻、心理社会功能改善以及医疗发病率降低。潜在风险包括死亡率、各种术后并发症、肝功能衰竭、肾结石以及失功能肠段细菌过度生长的后果。该手术用短肠的后果来换取治疗肥胖,并且仅应在有经验丰富的外科医生、内科医生和精神科医生团队能够提供必要的术前和术后管理的情况下进行。