Testa D, Savoiardo M, Fetoni V, Strada L, Palazzini E, Bertulezzi G, Girotti F
Dipartimento di Neurologia, Istituto Nazionale Neurologico C. Besta, Milano.
Ital J Neurol Sci. 1993 Apr;14(3):211-6. doi: 10.1007/BF02335661.
Probable or possible multiple system atrophy (MSA) was diagnosed on strict clinical criteria in 42 patients: 20 with combined parkinsonism and cerebellar ataxia, 9 with striatonigral degeneration (SND) and 13 with olivopontocerebellar atrophy (OPCA). All patients were then studied with 0.5 and/or 1.5 Tesla magnetic resonance (MR) units. MR imaged putaminal abnormalities in all 9 patients with SND and posterior fossa abnormalities consistent with OPCA in all 13 patients with this diagnosis. Of the 20 patients with parkinsonism and cerebellar involvement, classified as probable MSA, 7 presented putaminal abnormalities only, 3 abnormalities consistent with OPCA only and 10 a combination of both. These findings show strong MRI support for the clinical diagnosis of MSA.
根据严格的临床标准，42例患者被诊断为可能或疑似多系统萎缩（MSA）：20例合并帕金森综合征和小脑共济失调，9例为纹状体黑质变性（SND），13例为橄榄脑桥小脑萎缩（OPCA）。随后，所有患者均接受了0.5和/或1.5特斯拉磁共振（MR）检查。MR成像显示，所有9例SND患者均有壳核异常，所有13例诊断为此病的患者均有后颅窝异常，符合OPCA表现。在20例合并帕金森综合征和小脑受累、分类为可能MSA的患者中，7例仅有壳核异常，3例仅有符合OPCA的异常，10例两者兼有。这些发现表明MRI对MSA的临床诊断有强有力的支持。
