Soffronoff E C, Kaufmann B M, Connaughton J F
Am J Obstet Gynecol. 1977 Jan 1;127(1):4-9. doi: 10.1016/0002-9378(77)90305-2.
With the Evans blue technique, 178 plasma volume, blood volume, and red cell volume determinations were studied in 51 hypertensive and 35 normotensive gravidas. Hypertensive pregnancies were classified according to the American Committee on Maternal Welfare schema. A large range and overlap in plasma and blood volume determinations was found, but mean values in patients with hypertensive disease were significantly depressed when compared with normotensive gravidas. A decrease in red cell mass was observed only in the severe hypertensive group of women. In general, those hypertensive patients with plasma and blood volume determinations approaching those of the normotensive control patients were associated with a favorable maternal and fetal outcome. Extreme hypovolemia occurred in most pregnancies associated with severe hypertensive disease and evidence of uteroplacental insufficiency.
采用伊文思蓝技术，对51例高血压孕妇和35例血压正常孕妇进行了178次血浆容量、血容量和红细胞容量测定。高血压妊娠根据美国孕产妇福利委员会的方案进行分类。发现血浆和血容量测定值范围很广且有重叠，但与血压正常的孕妇相比，高血压疾病患者的平均值明显降低。仅在重度高血压女性组中观察到红细胞量减少。一般来说，那些血浆和血容量测定值接近血压正常对照患者的高血压患者，母婴结局良好。大多数与重度高血压疾病及子宫胎盘功能不全证据相关的妊娠中出现了极度血容量不足。
