Abe Y, Akiyama H, Arata J
Department of Dermatology, Okayama University Medical School, Japan.
J Dermatol. 1993 Apr;20(4):198-202. doi: 10.1111/j.1346-8138.1993.tb03861.x.
The pathomechanism of furuncle has not been fully elucidated and should be investigated using an appropriate animal model. We observed the invasion of Staphylococcus aureus cells into hair follicles in mice, using a strain of S. aureus isolated from human furunculosis. Light microscopical examination revealed that S. aureus cells attached to corneocytes at 6 h after inoculation, proliferated around the ostium of the hair follicle and invaded the hair follicle at 12 h after inoculation. Electron microscopically, S. aureus cells attached to the horny layer of hair follicle with long, thick, string-like structures. At 12 h after inoculation, S. aureus cells invaded in a file between the inner root sheath and outer root sheath. We could not induce direct invasion from the follicle ostium. Our findings suggest that there are some regions of the hair follicle through which S. aureus cells can relatively easily invade deeper into the follicle. The most important question is what confines the invasion and inflammation of S. aureus to the hair follicle. We suggest that there is some locus minoris for invasion into hair follicles by S. aureus, such as an interface between the two sheaths.
疖病的发病机制尚未完全阐明，应使用合适的动物模型进行研究。我们使用从人类疖病中分离出的一株金黄色葡萄球菌，观察了其在小鼠毛囊中的侵袭情况。光学显微镜检查显示，接种后6小时金黄色葡萄球菌细胞附着于角质形成细胞，在毛囊开口周围增殖，并在接种后12小时侵入毛囊。电子显微镜下，金黄色葡萄球菌细胞通过长而粗的丝状结构附着于毛囊角质层。接种后12小时，金黄色葡萄球菌细胞在内根鞘和外根鞘之间呈单列侵入。我们无法诱导其从毛囊开口直接侵入。我们的研究结果表明，毛囊存在一些区域，金黄色葡萄球菌细胞可相对容易地通过这些区域深入毛囊。最重要的问题是，是什么限制了金黄色葡萄球菌在毛囊内的侵袭和炎症反应。我们认为，存在一些金黄色葡萄球菌侵入毛囊的薄弱部位，比如两个鞘之间的界面。
