Mack E E, Wilson C B
Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
J Neurosurg. 1993 Jul;79(1):28-31. doi: 10.3171/jns.1993.79.1.0028.
Although meningiomas are known to be induced by low doses of cranial irradiation, such as those given to treat tinea capitis, little experience has been reported on the induction of meningiomas by high-dose cranial irradiation. The authors describe a series of 10 patients with meningiomas and a previous history of high-dose radiation therapy, usually given for a primary brain tumor. Of the 10 patients, eight were female, three had multiple meningiomas, and the majority had other stigmata of previous radiation therapy. Eight meningiomas were examined pathologically and one-half were classified as either aggressive or atypical, or were noted to have a high bromodeoxyuridine labeling index. The average time from radiation therapy to diagnosis of a meningioma was 24 years (range 5 to 40 years), a shorter interval than that previously reported for meningiomas induced by lower doses of irradiation. Within this series, patient age at irradiation was significantly correlated with tumor latency; individuals who were younger at the time of radiation therapy had a shorter time to meningioma formation. The latency of meningioma formation is therefore influenced by both the radiation dose and the age of the patient at irradiation.
尽管已知低剂量的头部照射（如用于治疗头癣的照射）可诱发脑膜瘤，但关于高剂量头部照射诱发脑膜瘤的报道却很少。作者描述了一组10例患有脑膜瘤且有高剂量放射治疗史的患者，这些高剂量放射治疗通常是针对原发性脑肿瘤进行的。在这10例患者中，8例为女性，3例有多发性脑膜瘤，大多数患者有既往放射治疗的其他体征。对8例脑膜瘤进行了病理检查，其中一半被归类为侵袭性或非典型性，或溴脱氧尿苷标记指数较高。从放射治疗到诊断出脑膜瘤的平均时间为24年（范围为5至40年），这一间隔时间比先前报道的低剂量照射诱发脑膜瘤的间隔时间要短。在该系列中，照射时患者的年龄与肿瘤潜伏期显著相关；放射治疗时年龄较小的个体形成脑膜瘤的时间较短。因此，脑膜瘤形成的潜伏期受放射剂量和照射时患者年龄的影响。
