Hussain A, al Khudhairi D
Department of Cardiac Anaesthesia, Armed Forces Cardiac Centre, Riyad, Kingdom of Saudi Arabia.
Middle East J Anaesthesiol. 1993 Feb;12(1):73-81.
A retrospective study of 28 neonates, admitted as emergencies with hypoxia due to inadequate pulmonary blood flow caused by congenital lesions in the pulmonary and/or tricuspid valves, showed a marked improvement in the degree of oxygenation after treatment with Prostaglandin E1 (PGE1) infusion. The side effects related to the PGE1 administration were observed, and were easily managed. The study demonstrates the efficacy of PGE1 in maintaining the patency of the ductus arteriosus; we therefore propose that this drug should be used, though with caution, routinely in peripheral hospitals before such patients are transferred to specialised centres for further diagnostic and therapeutic intervention.
一项对28例新生儿的回顾性研究表明，这些新生儿因肺和/或三尖瓣先天性病变导致肺血流量不足而作为急症入院，在输注前列腺素E1（PGE1）治疗后氧合程度有显著改善。观察到了与PGE1给药相关的副作用，且易于处理。该研究证明了PGE1在维持动脉导管通畅方面的疗效；因此，我们建议在将此类患者转至专科中心进行进一步诊断和治疗干预之前，外周医院应谨慎地常规使用该药。
