Dandona P, Menon R K, Shenoy R, Houlder S, Thomas M, Mallinson W J
J Clin Endocrinol Metab. 1986 Aug;63(2):459-62. doi: 10.1210/jcem-63-2-459.
The relationship among serum vitamin D metabolites, PTH, and osteocalcin concentrations was investigated in 20 elderly subjects. All except 2 had subnormal 25-hydroxyvitamin D concentrations. Eighteen (90%) had subnormal serum 1,25-dihydroxyvitamin D [1,25-(OH)2D] concentrations, while 8 subjects (40%) had elevated PTH concentrations. There was a highly significant inverse relationship between PTH and 1,25-(OH)2D concentrations. Serum osteocalcin concentrations were not elevated in any subject, and in fact, the mean osteocalcin concentration was in the lower part of the normal range. These data indicate no compensatory increase in 1,25-(OH)2D in response to secondary hyperparathyroidism and no increase in osteocalcin in response to hypersecretion of PTH in the elderly. These 2 defects may contribute to the bone disease of the elderly.
对20名老年受试者的血清维生素D代谢物、甲状旁腺激素（PTH）和骨钙素浓度之间的关系进行了研究。除2人外，所有人的25-羟基维生素D浓度均低于正常水平。18人（90%）的血清1,25-二羟基维生素D[1,25-(OH)2D]浓度低于正常水平，而8名受试者（40%）的PTH浓度升高。PTH与1,25-(OH)2D浓度之间存在高度显著的负相关关系。所有受试者的血清骨钙素浓度均未升高，事实上，骨钙素的平均浓度处于正常范围的下限。这些数据表明，老年受试者对继发性甲状旁腺功能亢进没有1,25-(OH)2D的代偿性增加，对PTH分泌过多也没有骨钙素增加。这两个缺陷可能导致老年人的骨病。
