Wiebe B M, Stenderup J, Grode G W, Jacobsen G K
Lungemedicinsk afdeling Y, Københavns Amts Sygehus i Gentofte.
Ugeskr Laeger. 1993 May 31;155(22):1722-3.
Coccidioidomycosis is an acute, generally mild, respiratory disease that rarely becomes chronic or disseminated and fatal. The aetiologic agent is Coccidioides immitis, a dimorphic fungus growing in soil. The fungus is endemic in hot semi-arid areas in the USA and South America. Human beings and animals become infected by inhaling dust with arthroconidia. The fungus gives rise to either a purulent or a granulomatous inflammation or both. Clinically and radiologically, it can be confused with neoplasms and tuberculosis. The disease may be fatal in immuno-deprived persons who are also at risk of reactivation of a latent infection. Coccidioidomycosis can be detected serologically. The standard treatment of severe illness is Amphotericin B. The authors present the first histologically and serologically verified case of pulmonary coccidioidomycosis in Denmark. An increased number of coccidioidomycosis can be expected with increased travelling and an increased number of immuno-deprived persons.
球孢子菌病是一种急性、通常较为轻微的呼吸道疾病，很少会发展为慢性、播散性且致命的疾病。病原体是球孢子菌，一种生长在土壤中的双相真菌。该真菌在美国和南美洲的炎热半干旱地区为地方病。人类和动物通过吸入含有关节孢子的灰尘而感染。该真菌可引发脓性或肉芽肿性炎症，或两者皆有。在临床和放射学上，它可能会与肿瘤和结核病相混淆。在免疫功能低下的人群中，该疾病可能是致命的，这些人也有潜伏感染再激活的风险。球孢子菌病可通过血清学检测出来。重症的标准治疗方法是使用两性霉素B。作者报告了丹麦首例经组织学和血清学证实的肺球孢子菌病病例。随着旅行人数的增加和免疫功能低下人群数量的增多，预计球孢子菌病的病例数会上升。
