用于脓毒症治疗的抗内毒素单克隆抗体。
Monoclonal antibodies to endotoxin in the management of sepsis.
作者信息
Fang K C
机构信息
Department of Medicine, University of California, School of Medicine, San Francisco.
出版信息
West J Med. 1993 Apr;158(4):393-9.
Abstract
New monoclonal antibodies directed against the lipid A moiety of the endotoxin present in gram-negative bacteria have been developed to improve the clinical outcome in patients with sepsis. Two studies of monoclonal antibodies HA-1A and E5 retrospectively identified specific patient subgroups showing benefit with therapy. I analyze and summarize the new sepsis nomenclature, the structure of endotoxin, the data implicating endotoxin as a causative agent in septic patients' morbidity and mortality, and specific data from the 2 clinical studies of monoclonal antibody therapy.
摘要
已研发出针对革兰氏阴性菌中内毒素脂质A部分的新型单克隆抗体，以改善脓毒症患者的临床结局。两项关于单克隆抗体HA - 1A和E5的研究回顾性地确定了显示治疗有益的特定患者亚组。我分析并总结了新的脓毒症命名法、内毒素的结构、表明内毒素是脓毒症患者发病和死亡病因的相关数据，以及单克隆抗体治疗两项临床研究的具体数据。
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