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Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine.

作者信息

Labadarios D, Davis M, Portmann B, Williams R

出版信息

Biochem Pharmacol. 1977 Jan 1;26(1):31-5. doi: 10.1016/0006-2952(77)90126-5.

DOI:10.1016/0006-2952(77)90126-5
PMID:831725
Abstract
摘要

相似文献

1
Paracetamol-induced hepatic necrosis in the mouse-relationship between covalent binding, hepatic glutathione depletion and the protective effect of alpha-mercaptopropionylglycine.对乙酰氨基酚诱导的小鼠肝坏死——共价结合、肝脏谷胱甘肽耗竭与α-巯基丙酰甘氨酸保护作用之间的关系
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2
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Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.对乙酰氨基酚导致肝谷胱甘肽耗竭、共价结合及肝坏死的种属差异。
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Effect of 2-mercaptopropionylglycine and 2-aminoethyl isothiuronium bromide hydrobromide on leucocytes in peripheral blood after gamma ray exposure in mice.2-巯基丙酰甘氨酸和氢溴酸2-氨基乙基异硫脲对γ射线照射后小鼠外周血白细胞的影响。
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Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.用4-苯基丁酸预处理或后处理对小鼠扑热息痛过量诱导的肝损伤的保护作用。
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引用本文的文献

1
Amelioration of hepatotoxicity by biocleavable aminothiol chimeras of isoniazid: Design, synthesis, kinetics and pharmacological evaluation.异烟肼可生物裂解氨基硫醇嵌合体对肝毒性的改善:设计、合成、动力学及药理学评价
World J Hepatol. 2018 Jul 27;10(7):496-508. doi: 10.4254/wjh.v10.i7.496.
2
Paracetamol overdosage. Pharmacological considerations and clinical management.对乙酰氨基酚过量。药理学考量与临床处理
Drugs. 1983 Mar;25(3):290-314. doi: 10.2165/00003495-198325030-00002.
3
Selective inhibition of acetaminophen oxidation and toxicity by cimetidine and other histamine H2-receptor antagonists in vivo and in vitro in the rat and in man.
西咪替丁及其他组胺H2受体拮抗剂在大鼠和人体体内及体外对乙酰氨基酚氧化和毒性的选择性抑制作用。
J Clin Invest. 1984 Feb;73(2):383-91. doi: 10.1172/JCI111223.
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Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethylmaleate poisoning and its relation to lipid peroxidation and necrosis.溴苯、碘苯和马来酸二乙酯中毒诱导的肝脏谷胱甘肽耗竭及其与脂质过氧化和坏死的关系。
Am J Pathol. 1985 Feb;118(2):225-37.
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Non-narcotic analgesics. Problems of overdosage.非麻醉性镇痛药。过量用药问题。
Drugs. 1986;32 Suppl 4:177-205. doi: 10.2165/00003495-198600324-00013.