Ahluwalia A, Flower R J
Department of Biochemical Pharmacology, William Harvey Research Institute, St. Bartholomew's Medical College, London, UK.
Agents Actions. 1993;38 Spec No:C16-8. doi: 10.1007/BF01991123.
Using a non-invasive laser Doppler velocimetry technique to measure skin blood flow in the rat skin, we have shown that chronic treatment with capsaicin inhibited the vasodilator response to a non-pathological, local heat (44 degrees C, 20 min duration) stimulus. However, sympathectomy, accomplished with chronic treatment of guanethidine, had no effect on this heat-induced vasodilation. Topical steroids have also been shown to inhibit this response thus, since the heat-dilator response appears from these results to be brought about by the release of sensory neuropeptides, the sensory neuron may be a target for topical steroid action.
我们使用一种非侵入性激光多普勒测速技术来测量大鼠皮肤中的皮肤血流量，结果表明，辣椒素的长期治疗会抑制对非病理性局部热刺激（44摄氏度，持续20分钟）的血管舒张反应。然而，用胍乙啶进行长期治疗实现的交感神经切除术，对这种热诱导的血管舒张没有影响。局部使用类固醇也已被证明会抑制这种反应。因此，从这些结果来看，由于热舒张反应似乎是由感觉神经肽的释放引起的，感觉神经元可能是局部类固醇作用的靶点。
