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Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.

作者信息

Lefer A M, Ma X L, Weyrich A, Lefer D J

机构信息

Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.

出版信息

Agents Actions Suppl. 1993;41:127-35.

PMID:8317336
Abstract

We measured changes in basal release of nitric oxide (NO) and its effect on polymorphonuclear neutrophil (PMN) adherence to endothelial cells (EC) in a feline model of myocardial ischemia and reperfusion (MI/R). Significant reductions in basal NO release occurred 10 minutes following reperfusion, whereas increases in PMN adherence occurred at 20 minutes post-reperfusion. Addition of hSOD blocked the post-reperfusion adherence of PMNs to the endothelium. These results indicate that decreased basal release of NO, following MI/R precedes enhanced PMN adherence to the coronary endothelium, which may lead to PMN-induced myocardial injury.

摘要

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