Salazar-Lindo E, Salazar M, Alvarez J O
Department of Pediatrics, Universidad Peruana, Cayetano Heredia.
Am J Clin Nutr. 1993 Jul;58(1):110-3. doi: 10.1093/ajcn/58.1.110.
To examine the relationship between acute diarrhea and vitamin A status, a study was conducted in 137 children (72 with diarrhea and 65 illness-free control subjects) in the city of Lima, Peru. Serum retinol was measured spectrophotometrically in samples collected in 1987 and kept frozen until they were analyzed simultaneously in 1989. Serum retinol was significantly lower in the children with diarrhea (mean +/- SD: 0.51 +/- 0.48 mumol/L) than in those without diarrhea (1.00 +/- 0.32 mumol/L; 1 mumol/L retinol = 28.6 micrograms/dL). The multivariate estimate of the effect of diarrhea (-0.464 mumol/L) in a model that incorporated age, sex, and acute malnutrition (ie, weight-for-height) as confounding variables was essentially the same as the unadjusted difference (-0.492 mumol/L). Thus, this model showed that the retinol concentration in the serum depends greatly on the presence of diarrhea. These findings suggest that diarrhea, as has been shown for other infections, may lead to lower circulating retinol concentrations and perhaps to its depletion.
为了研究急性腹泻与维生素A状况之间的关系，在秘鲁利马市对137名儿童（72名腹泻儿童和65名无病对照儿童）进行了一项研究。1987年采集样本并冷冻保存，直至1989年同时进行分析，采用分光光度法测定血清视黄醇。腹泻儿童的血清视黄醇水平（均值±标准差：0.51±0.48μmol/L）显著低于无腹泻儿童（1.00±0.32μmol/L；1μmol/L视黄醇 = 28.6μg/dL）。在一个纳入年龄、性别和急性营养不良（即身高别体重）作为混杂变量的模型中，腹泻影响（-0.464μmol/L）的多变量估计值与未调整差异（-0.492μmol/L）基本相同。因此，该模型表明血清视黄醇浓度在很大程度上取决于腹泻的存在。这些发现表明，正如其他感染所显示的那样，腹泻可能导致循环视黄醇浓度降低，甚至可能导致其耗竭。
