Alvarez J O, Salazar-Lindo E, Kohatsu J, Miranda P, Stephensen C B
Department of International Health, University of Alabama at Birmingham 35294-0008, USA.
Am J Clin Nutr. 1995 Jun;61(6):1273-6. doi: 10.1093/ajcn/61.6.1273.
Acute infections of childhood are associated with an increased of xerophthalmia, apparently due to depletion of vitamin A stores. The mechanism responsible for this is not known. Recently, it has been reported that severe infections in adult patients (ie, sepsis and pneumonia) result in excretion of large quantities of retinol in the urine. In 44 children hospitalized for treatment of acute diarrhea we found mean urinary excretions of 1.44 mumol retinol/24 h on day 1 of hospitalization, 0.62 mumol retinol/24 h on day 2, and 0.23 mumol/24 h on day 3. Healthy control subjects matched for age did not excrete measurable amounts of retinol in the urine. Retinol excretion was associated strongly with rotavirus diarrhea and presence of fever. Furthermore, serum retinol concentration was negatively associated with duration of diarrhea before hospitalization, suggesting that urinary excretion of retinol may be an important contributor to vitamin A depletion.
儿童急性感染与干眼病增加有关，这显然是由于维生素A储备耗竭所致。其 responsible for this的机制尚不清楚。最近，有报道称成年患者的严重感染（即败血症和肺炎）会导致尿液中大量视黄醇排出。在44名因急性腹泻住院治疗的儿童中，我们发现住院第1天尿视黄醇平均排泄量为1.44 μmol/24小时，第2天为0.62 μmol/24小时，第3天为0.23 μmol/24小时。年龄匹配的健康对照受试者尿液中未排出可测量量的视黄醇。视黄醇排泄与轮状病毒腹泻和发热密切相关。此外，血清视黄醇浓度与住院前腹泻持续时间呈负相关，提示视黄醇的尿排泄可能是维生素A耗竭的一个重要因素。 （注：原文中“responsible for this”这样表述不太准确和完整，翻译时尽量按原文呈现）
