Tepper S, Hochberg M C
Department of Mental Hygiene, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD.
Am J Epidemiol. 1993 May 15;137(10):1081-8. doi: 10.1093/oxfordjournals.aje.a116611.
Factors associated with hip osteoarthritis were studied in 2,490 subjects aged 55-74 years using data from the First National Health and Nutrition Examination Survey (NHANES-I). Pelvic radiographs were read for hip osteoarthritis using Kellgren-Lawrence scales; cases were defined by grade > or = 2 changes. Subjects with missing radiographs and other data and those with grade 1 radiographic changes (n = 132) were excluded from analyses. Crude and adjusted odds ratios and 95% confidence intervals (CIs) were estimated from logistic regression analyses. Overall, the crude prevalence of hip osteoarthritis was 3.1% (73 of 2,358); 42 cases were unilateral, and 31 cases were bilateral. Age was significantly associated with hip osteoarthritis (adjusted odds ratios = 1.30 (95% CI 0.60-2.81), 1.69 (95% CI 0.83-3.44), and 2.38 (95% CI 1.15-4.92) for ages 60-64, 65-69, and 70-74, respectively). Other sociodemographic factors, obesity, and fat distribution were not associated with hip osteoarthritis. Age and hip trauma were strongly associated with hip osteoarthritis among men; however, among women, no factors were significantly associated with hip osteoarthritis. Hip trauma was significantly associated with unilateral but not bilateral hip osteoarthritis, while obesity was associated with bilateral but not unilateral hip osteoarthritis. These data suggest that etiologic factors associated with hip osteoarthritis may differ for males and females and for unilateral and bilateral hip osteoarthritis.
利用首次全国健康和营养检查调查(NHANES - I)的数据,对2490名年龄在55 - 74岁的受试者进行了与髋骨关节炎相关因素的研究。使用凯尔格伦 - 劳伦斯量表对骨盆X光片进行髋骨关节炎的判读;病例定义为分级≥2级的改变。分析中排除了X光片及其他数据缺失的受试者以及X光片分级为1级的受试者(n = 132)。通过逻辑回归分析估计了粗比值比和调整后的比值比以及95%置信区间(CIs)。总体而言,髋骨关节炎的粗患病率为3.1%(2358人中73人);42例为单侧,31例为双侧。年龄与髋骨关节炎显著相关(60 - 64岁、65 - 69岁和70 - 74岁的调整后比值比分别为1.30(95% CI 0.60 - 2.81)、1.69(95% CI 0.83 - 3.44)和2.38(95% CI 1.15 - 4.92))。其他社会人口学因素、肥胖和脂肪分布与髋骨关节炎无关。年龄和髋部创伤在男性中与髋骨关节炎密切相关;然而,在女性中,没有因素与髋骨关节炎显著相关。髋部创伤与单侧而非双侧髋骨关节炎显著相关,而肥胖与双侧而非单侧髋骨关节炎相关。这些数据表明,与髋骨关节炎相关的病因因素在男性和女性以及单侧和双侧髋骨关节炎中可能有所不同。