Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.
作者信息
Kulkarni A B, Karlsson S
机构信息
Molecular Medical Genetics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
出版信息
Am J Pathol. 1993 Jul;143(1):3-9.
Abstract
摘要
相似文献
1
Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease.
Am J Pathol. 1993 Jul;143(1):3-9.
2
Induction of the alpha(1)-antichymotrypsin gene in the brain associated with TGF-beta1 deficiency or systemic administration of endotoxin.
Biochem Biophys Res Commun. 1999 Sep 24;263(2):270-5. doi: 10.1006/bbrc.1999.1373.
3
High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells.
Circulation. 2005 May 31;111(21):2805-11. doi: 10.1161/CIRCULATIONAHA.104.472886. Epub 2005 May 23.
4
Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model.
Eur J Immunol. 2005 Jan;35(1):198-206. doi: 10.1002/eji.200425209.
5
Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice.
Am J Pathol. 1997 Nov;151(5):1281-8.
6
Immunological studies of chronic ocular toxoplasmosis: up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6.
Infect Immun. 2001 Apr;69(4):2589-95. doi: 10.1128/IAI.69.4.2589-2595.2001.
7
IL-10 gene-deficient mice lack TGF-beta/Smad-mediated TLR2 degradation and fail to inhibit proinflammatory gene expression in intestinal epithelial cells under conditions of chronic inflammation.
Ann N Y Acad Sci. 2006 Aug;1072:389-94. doi: 10.1196/annals.1326.023.
8
Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.
J Immunol. 1999 Oct 1;163(7):4013-9.
9
Transforming growth factor-beta-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis.
Biochem Soc Trans. 2006 Dec;34(Pt 6):1141-4. doi: 10.1042/BST0341141.
10
Differential expression of TGF-beta, IL-2, and other cytokines in the CNS of Theiler's murine encephalomyelitis virus-infected susceptible and resistant strains of mice.
Virology. 2000 Dec 20;278(2):346-60. doi: 10.1006/viro.2000.0646.
引用本文的文献
1
GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors.
Cancer Immunol Immunother. 2025 Sep 13;74(10):308. doi: 10.1007/s00262-025-04157-2.
2
First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti-PD-1 antibody budigalimab in patients with advanced solid tumors.
Front Oncol. 2024 Oct 29;14:1376551. doi: 10.3389/fonc.2024.1376551. eCollection 2024.
3
Endocardial HDAC3 is required for myocardial trabeculation.
Nat Commun. 2024 May 16;15(1):4166. doi: 10.1038/s41467-024-48362-6.
4
Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration.
Pharmacol Ther. 2024 May;257:108638. doi: 10.1016/j.pharmthera.2024.108638. Epub 2024 Mar 26.
5
Hitting the Target! Challenges and Opportunities for TGF-β Inhibition for the Treatment of Cardiac fibrosis.
Pharmaceuticals (Basel). 2024 Feb 20;17(3):267. doi: 10.3390/ph17030267.
6
Smad4-deficient T cells promote colitis-associated colon cancer an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.
Front Immunol. 2022 Aug 15;13:932412. doi: 10.3389/fimmu.2022.932412. eCollection 2022.
7
TGF-β1 mediates pathologic changes of secondary lymphedema by promoting fibrosis and inflammation.
Clin Transl Med. 2022 Jun;12(6):e758. doi: 10.1002/ctm2.758.
8
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity.
Front Immunol. 2021 Feb 26;12:597761. doi: 10.3389/fimmu.2021.597761. eCollection 2021.
9
TGFβ signaling networks in ovarian cancer progression and plasticity.
Clin Exp Metastasis. 2021 Apr;38(2):139-161. doi: 10.1007/s10585-021-10077-z. Epub 2021 Feb 15.
10
Complex Relationship Between Cardiac Fibroblasts and Cardiomyocytes in Health and Disease.
J Am Heart Assoc. 2021 Feb;10(5):e019338. doi: 10.1161/JAHA.120.019338. Epub 2021 Feb 15.
本文引用的文献
1
Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).
Growth Factors. 1993;8(1):1-9. doi: 10.3109/08977199309029129.
2
Shutdown of class switch recombination by deletion of a switch region control element.
Science. 1993 Feb 12;259(5097):984-7. doi: 10.1126/science.8438159.
3
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):770-4. doi: 10.1073/pnas.90.2.770.
4
Establishment in culture of pluripotential cells from mouse embryos.
Nature. 1981 Jul 9;292(5819):154-6. doi: 10.1038/292154a0.
5
HPRT-deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells.
Nature. 1987;326(6110):292-5. doi: 10.1038/326292a0.
6
A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice.
Nature. 1987;326(6110):295-8. doi: 10.1038/326295a0.
7
The new mouse genetics: altering the genome by gene targeting.
Trends Genet. 1989 Mar;5(3):70-6. doi: 10.1016/0168-9525(89)90029-2.
8
Altering the genome by homologous recombination.
Science. 1989 Jun 16;244(4910):1288-92. doi: 10.1126/science.2660260.
9
TGF-beta stimulation and inhibition of cell proliferation: new mechanistic insights.
Cell. 1990 Oct 19;63(2):245-7. doi: 10.1016/0092-8674(90)90155-8.
10
The transforming growth factor-beta family.
Annu Rev Cell Biol. 1990;6:597-641. doi: 10.1146/annurev.cb.06.110190.003121.
Zotero 插件