Ladds P W, Entwistle K W
Br J Cancer. 1977 Jan;35(1):110-4. doi: 10.1038/bjc.1977.10.
Observations were made over a 4-year period on squamous cell carcinomas on the ear and other areas poorly covered by hair or wool, sheep pastured in the hot, dry environment of north-western Queensland. Overall incidence in the flock was higher than in flocks kept at greater latitudes. Increased incidence with advancing age was demonstrated, and ewes appeared to be more susceptible than wethers. Metastases were observed in 4 of 33 affected ewes (12%) submitted to detailed necropsy examination. Measurements of tumour growth in 4 ewes revealed an increase in size of about 3-5 mm per month. Ovine aural squamous cell carcinoma was considered to be a good model for studies on skin cancer in man.
在4年时间里，对昆士兰西北部炎热干燥环境中放牧的绵羊耳部及其他毛发或羊毛覆盖较少区域的鳞状细胞癌进行了观察。该羊群的总体发病率高于在更高纬度地区饲养的羊群。研究表明，发病率随年龄增长而增加，且母羊似乎比公羊更易患病。在33只接受详细尸检的患病母羊中，有4只（12%）出现转移。对4只母羊肿瘤生长情况的测量显示，肿瘤大小每月增加约3 - 5毫米。绵羊耳部鳞状细胞癌被认为是研究人类皮肤癌的良好模型。
